Models to Combat
Cancer & Aging
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Aging intervention and phenotyping facility
Step
2. Intervention

Aging intervention and phenotyping facility

Offering detailed phenotyping services and tailor-made intervention studies on aging and age-related metabolic diseases

What we study & facilitate

Complete phenotyping for age-related diseases

The Aging Intervention and Phenotyping Facility provides services from two sites: UMCG in Groningen and Erasmus MC in Rotterdam. 

We offer complete phenotyping for age-related diseases. At our UMCG location the focus lies on detailed phenotyping services on aging and age-related metabolic diseases. The Erasmus MC location provides unique complimentary services including a large collection of accelerated aging mouse models and tailor-made intervention studies.  


MicroCT 3D heart of wild type mouse model (Erasmus MC)
MicroCT 3D heart of wild type mouse model (Erasmus MC)

Our approach

A combination of behavioral, physical and metabolic tests

The facility provides a combination of behavioral, physical and metabolic tests to study the mechanism of ageing and (age-related) diseases, and offers studies in mouse models for accelerated aging both systemic and tissue-specific, generated and validated in-house.


Our goal

Provide novel intervention strategies that combat age-related disease

Our goal is to provide novel intervention strategies that combat age-related disease on the unique aging and senescence models available in a well-controlled setting with our expertise and infrastructure for tailored and in-depth phenotypic analysis of mouse models of (accelerated) aging. We also intend to capture and share mouse data generated within the facilities to make these available to the larger research community, thereby limiting unnecessary repetition of animal experiments. 


our research and development

Standardized nutritional and pharmacological experiments

The services we provide are standardized nutritional and pharmacological experiments that combat age-related disease on unique models available, in a controlled setting to maximize output and minimize animal use. We offer a broad range of experimental set-ups, e.g., for neurological and cardiovascular diseases, both important when we consider the growing aging population.


our Expertise, techniques & equipment

Behavior/cognition testing, body composition analysis, metabolic and physical parameters

Our current phenotyping pipeline includes behavior/cognition testing, body composition analysis, metabolic and physical parameters as well as frailty parameters. At the UMCG we offer unique Metabolic Flux Analysis using stable isotopes (i.e., determination of rate of metabolic reactions). At the Erasmus MC facility, we implement the extensive expertise and sophisticated infrastructure for detailed neurological analysis (e.g., the Erasmus Ladder which scores detailed motor performance, learning and memory), and investigation of the cardiological, vascular, skeletal, hematopoietic and hormonal systems in the aging mouse models. 


Location & facility contact

How can we help with your research?
Do you need answers to your in-depth research question? Want more information about our expertise, research or facility? Looking for a quote or an answer to something else? Please feel free to contact the facility leaders.
Location(s) of this facility
Dr. Ingrid van der Pluijm
Principal investigator Cardiovascular Aging
i.vanderpluijm@erasmusmc.nl
Prof.dr. Hans Jonker
Professor of Molecular Regulation of Metabolism
j.w.jonker@umcg.nl

All our facilities

Contact MCCA

For all general inquiries about MCCA, our facilities and services or how we can help with your research to combat cancer and aging, please contact Els Hermans or Marieke van de Ven.
Marieke van de Ven
Netherlands Cancer Institute, Amsterdam, The Netherlands
Els Hermans
Netherlands Cancer Institute, Amsterdam, The Netherlands

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