Models to Combat
Cancer & Aging
About the consortium
a Consortium of Dutch research institutes

A joint effort to facilitate groundbreaking research

The Models to Combat Cancer and Aging (MCCA) consortium is the Dutch infrastructure network for development and utilization of preclinical models in basic and translational cancer and aging-related research.
The MCCA is the Dutch partner in the European INFRAFRONTIER and EUROPDX infrastructures. Participants are The Netherlands Cancer Institute (NKI), Erasmus MC (EMC), UMCG Research (UMCG), University of Utrecht (UU), Hubrecht Institute and Princess Máxima Center (PMC).
People behind the research & development

The MCCA team

Facility leaders
Key researchers
Scientific advisory board
All MCCA members
Dr. Paul Krimpenfort
Dr. Paul Krimpenfort
Transgenic technology, molecular genetics, immunology
Netherlands Cancer Institute
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ORCID profile
Prof.dr. Bart van de Sluis
Prof.dr. Bart van de Sluis
,
Aging, Genetics, Mouse Models, Dyslipidemia and liver disease
UMCG
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ORCID profile
Dr. Anne Rios
Dr. Anne Rios
,
Human tissue models, 3D imaging
Princess Máxima Center
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ORCID profile
Prof.dr. Hans Clevers
Prof.dr. Hans Clevers
,
Organoid technology, human disease modeling
Hubrecht Institute
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ORCID profile
Prof.dr. Roland Kanaar
Prof.dr. Roland Kanaar
,
Cancer, Molecular Biology, Genetics
Erasmus MC
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ORCID profile
Dr. Marieke van de Ven
Dr. Marieke van de Ven
Preclinical intervention studies, genetics, molecular biology
Netherlands Cancer Institute
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ORCID profile
Prof.dr. Rob Coppes
Prof.dr. Rob Coppes
,
Cancer, Radiation Biology, Particle therapy, Organoids
UMCG
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ORCID profile
Dr. Ingrid van der Pluijm
Dr. Ingrid van der Pluijm
Cardiovascular aging, aging mouse models, intervention studies
Erasmus MC
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ORCID profile
Prof.dr. Hans Jonker
Prof.dr. Hans Jonker
,
Aging, Molecular genetics, Type 2 diabetes, Non-alcoholic fatty liver disease
UMCG
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ORCID profile
Prof.dr. Alain de Bruin
Prof.dr. Alain de Bruin
,
Anatomic and Molecular Pathology in Cancer & Aging
University of Utrecht
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ORCID profile
Dr. Sjoerd Klarenbeek
Dr. Sjoerd Klarenbeek
Comparative and experimental pathology
Netherlands Cancer Institute
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ORCID profile
Dr. Monique Bernsen
Dr. Monique Bernsen
,
High resolution and molecular imaging, Theragnostic
Erasmus MC
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ORCID profile
Prof.dr. Jacco van Rheenen
Prof.dr. Jacco van Rheenen
,
Cancer, High resolution intra-vital microscopy
Netherlands Cancer Institute
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ORCID profile
Prof.dr. Jos Jonkers
Prof.dr. Jos Jonkers
,
Genetics, Mouse models, DNA repair, breast cancer
Netherlands Cancer Institute
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ORCID profile
Prof.dr. Karin de Visser
Prof.dr. Karin de Visser
Tumor Biology, Immunology, Metastasis, Breast Cancer
Netherlands Cancer Institute
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ORCID profile
Dr. Leila Akkari
Dr. Leila Akkari
Tumor Biology, Immunology, TME, Cancer Treatment, Imaging
Netherlands Cancer Institute
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ORCID profile
Dr. Jeroen Essers
Dr. Jeroen Essers
In vivo molecular imaging
Erasmus MC
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ORCID profile
Dr. Marco Demaria
Dr. Marco Demaria
Aging, cellular senescence, Cancer, Tissue repair, Aging models and reporter models
UMCG
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ORCID profile
Prof.dr. Jan Hoeijmakers
Prof.dr. Jan Hoeijmakers
DNA damage repair, aging and cancer, mouse models, repair syndromes
Erasmus MC
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ORCID profile
Dr. Dik van Gent
Dr. Dik van Gent
DNA repair, DNA damaging anti-cancer treatment, culturing organotypic tumor slices ex vivo
Erasmus MC
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ORCID profile
Dr. Olaf van Tellingen
Dr. Olaf van Tellingen
preclinical pharmacology, brain tumors, blood-brain barrier
Netherlands Cancer Institute
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ORCID profile
Prof.dr. Bart van de Sluis
Prof.dr. Bart van de Sluis
,
Aging, Genetics, Mouse Models, Dyslipidemia and liver disease
UMCG
Profile page
ORCID profile
Dr. Anne Rios
Dr. Anne Rios
,
Human tissue models, 3D imaging
Princess Máxima Center
Profile page
ORCID profile
Prof.dr. Hans Clevers
Prof.dr. Hans Clevers
,
Organoid technology, human disease modeling
Hubrecht Institute
Profile page
ORCID profile
Prof.dr. Roland Kanaar
Prof.dr. Roland Kanaar
,
Cancer, Molecular Biology, Genetics
Erasmus MC
Profile page
ORCID profile
Prof.dr. Rob Coppes
Prof.dr. Rob Coppes
,
Cancer, Radiation Biology, Particle therapy, Organoids
UMCG
Profile page
ORCID profile
Prof.dr. Hans Jonker
Prof.dr. Hans Jonker
,
Aging, Molecular genetics, Type 2 diabetes, Non-alcoholic fatty liver disease
UMCG
Profile page
ORCID profile
Prof.dr. Alain de Bruin
Prof.dr. Alain de Bruin
,
Anatomic and Molecular Pathology in Cancer & Aging
University of Utrecht
Profile page
ORCID profile
Dr. Monique Bernsen
Dr. Monique Bernsen
,
High resolution and molecular imaging, Theragnostic
Erasmus MC
Profile page
ORCID profile
Prof.dr. Jacco van Rheenen
Prof.dr. Jacco van Rheenen
,
Cancer, High resolution intra-vital microscopy
Netherlands Cancer Institute
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ORCID profile
Dr. Vera Gorbunova
Dr. Vera Gorbunova
aging, molecular biology, therapeutics

University of Rochester, New York, United States

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Prof.dr. Martin Hrabě de Angelis
Prof.dr. Martin Hrabě de Angelis
Genomics, diabetes

Helmholtz Zentrum, München, Germany

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Prof. Paul Workman
Prof. Paul Workman
multidisciplinary cancer drug discovery

The Institute of Cancer Research, London, United Kingdom

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ORCID profile
Dr. Violeta Serra
Dr. Violeta Serra
Breast cancer, pdx, organoids

Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain

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Prof.dr. Geert Kops
Prof.dr. Geert Kops
chromosome segregation

Oncode Institute, Utrecht, The Netherlands

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ORCID profile
Dr. Catelijne Stortelers
Dr. Catelijne Stortelers
Therapeutical Biologics

VIB Discovery Sciences, Leuven, Belgium

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Prof.dr. David Tuveson
Prof.dr. David Tuveson
Organoids and CoC, Model organisms in oncology

Cold Spring Harbor Laboratory Cancer Center, Huntington, United States

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ORCID profile
Prof.dr. Mario van der Stelt
Prof.dr. Mario van der Stelt
drug discovery, medicinal chemistry, chemical biology

Leiden University, Leiden, The Netherlands

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ORCID profile
Dr. Zinaida Perova
Dr. Zinaida Perova
cancer models

European Bioinformatics Institute (EMBL-EBI), Cambridge, United Kingdom

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ORCID profile
Prof.dr. Jos Jonkers
Prof.dr. Jos Jonkers
,
Netherlands Cancer Institute
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ORCID profile
Dr. Els Hermans
Dr. Els Hermans
Netherlands Cancer Institute
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ORCID profile
Prof.dr. Karin de Visser
Prof.dr. Karin de Visser
Netherlands Cancer Institute
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ORCID profile
Dr. Leila Akkari
Dr. Leila Akkari
Netherlands Cancer Institute
Profile page
ORCID profile
Dr. Jeroen Essers
Dr. Jeroen Essers
Erasmus MC
Profile page
ORCID profile
Prof.dr. Jan Hoeijmakers
Prof.dr. Jan Hoeijmakers
Erasmus MC
Profile page
ORCID profile
Dr. Dik van Gent
Dr. Dik van Gent
Erasmus MC
Profile page
ORCID profile
Dr. Paul Krimpenfort
Dr. Paul Krimpenfort
Netherlands Cancer Institute
Profile page
ORCID profile
Dr. Olaf van Tellingen
Dr. Olaf van Tellingen
Netherlands Cancer Institute
Profile page
ORCID profile
Dr. Anne Rios
Dr. Anne Rios
,
Princess Máxima Center
Profile page
ORCID profile
Prof.dr. Hans Clevers
Prof.dr. Hans Clevers
,
Hubrecht Institute
Profile page
ORCID profile
Dr. Marieke van de Ven
Dr. Marieke van de Ven
Netherlands Cancer Institute
Profile page
ORCID profile
Dr. Ingrid van der Pluijm
Dr. Ingrid van der Pluijm
Erasmus MC
Profile page
ORCID profile
Prof.dr. Alain de Bruin
Prof.dr. Alain de Bruin
,
University of Utrecht
Profile page
ORCID profile
Dr. Sjoerd Klarenbeek
Dr. Sjoerd Klarenbeek
Netherlands Cancer Institute
Profile page
ORCID profile
Prof.dr. Jacco van Rheenen
Prof.dr. Jacco van Rheenen
,
Netherlands Cancer Institute
Profile page
ORCID profile
Dr. Vera Gorbunova
Dr. Vera Gorbunova
Netherlands Cancer Institute
Profile page
ORCID profile
Prof.dr. Martin Hrabě de Angelis
Prof.dr. Martin Hrabě de Angelis
Netherlands Cancer Institute
Profile page
ORCID profile
Prof. Paul Workman
Prof. Paul Workman
Netherlands Cancer Institute
Profile page
ORCID profile
Dr. Violeta Serra
Dr. Violeta Serra
Netherlands Cancer Institute
Profile page
ORCID profile
Prof.dr. Geert Kops
Prof.dr. Geert Kops
Oncode Institute
Profile page
ORCID profile
Dr. Catelijne Stortelers
Dr. Catelijne Stortelers
Netherlands Cancer Institute
Profile page
ORCID profile
Prof.dr. David Tuveson
Prof.dr. David Tuveson
Netherlands Cancer Institute
Profile page
ORCID profile
Prof.dr. Mario van der Stelt
Prof.dr. Mario van der Stelt
Netherlands Cancer Institute
Profile page
ORCID profile
Dr. Zinaida Perova
Dr. Zinaida Perova
Netherlands Cancer Institute
Profile page
ORCID profile

Contact MCCA

For all general inquiries about MCCA, our facilities and services or how we can help with your research to combat cancer and aging, please contact Els Hermans or Jos Jonkers.
Jos Jonkers, consortium coordinator
j.jonkers@nki.nl
Netherlands Cancer Institute, Amsterdam, The Netherlands
Els Hermans, project manager
e.hermans@nki.nl
Netherlands Cancer Institute, Amsterdam, The Netherlands

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